Quick Verdict

The Philips Sonicare ProtectiveClean 5300 and Oral-B iO Series 5 are the sweet spots in their respective lineups—delivering most premium features at mid-range prices. The ProtectiveClean 5300 is the better value at ~$80, while the iO Series 5 justifies its ~$130 price with superior smart features. Both will dramatically improve your brushing versus a manual toothbrush.

Head-to-Head Comparison

Cleaning Technology

Winner: Oral-B iO Series 5

The iO Series 5 uses Oral-B's magnetic drive technology, delivering precise oscillating-rotating-pulsating action. Clinical studies show superior plaque removal, especially along the gumline where cavities often start.

The ProtectiveClean 5300 delivers 62,000 brush movements per minute—proven effective, but the cleaning action is less targeted than oscillating brushes.

For raw plaque removal effectiveness, the iO technology has an edge.

Value for Money

Winner: Philips Sonicare ProtectiveClean 5300

At ~$80, the ProtectiveClean 5300 includes the brush handle, charging base, travel case, and 3 brush heads. That's everything you need for months of use.

The iO Series 5 at ~$130 typically includes only 1 brush head, and replacement iO heads cost more than Sonicare heads.

For pure value, the ProtectiveClean 5300 delivers more for less.

Smart Features

Winner: Oral-B iO Series 5

The iO Series 5 features an interactive color display, AI-powered position recognition, and real-time brushing guidance in the app. It tracks your brushing across zones and provides personalized feedback.

The ProtectiveClean 5300 has no smart features—no app, no Bluetooth, no display. It relies on BrushSync for replacement reminders only.

If smart features matter to you, the iO Series 5 is significantly better.

Cleaning Modes

Winner: Oral-B iO Series 5

The iO Series 5 offers 5 modes: Daily Clean, Intense, Sensitive, Whitening, and Gum Care. Each serves a distinct purpose.

The ProtectiveClean 5300 offers 3 modes: Clean, White, and Gum Care. Fewer options, but covers the essentials.

For mode variety, the iO Series 5 wins.

Gum Protection

Winner: Tie

Both feature pressure sensors that alert you when brushing too hard—critical for protecting gum health.

The ProtectiveClean 5300's pressure sensor pauses pulsations and makes an audible alert. The iO Series 5's pressure sensor uses visual feedback via the display (red light for too hard).

Both approaches work well. The ProtectiveClean's automatic pause may be more effective for those who don't watch the display.

Battery Life

Winner: Philips Sonicare ProtectiveClean 5300

The ProtectiveClean 5300 lasts 14 days on a single charge. The iO Series 5 lasts about 7 days under similar usage.

For travelers or those who prefer less frequent charging, Sonicare wins.

Build Quality & Design

Winner: Oral-B iO Series 5

The iO Series 5 features premium build quality with an interactive display and refined ergonomics. It looks and feels like a premium device.

The ProtectiveClean 5300 has solid build quality but a more utilitarian design. No display, just LED indicators.

For aesthetics and premium feel, the iO wins.

Replacement Brush Head Costs

Winner: Philips Sonicare ProtectiveClean 5300

Sonicare heads: ~$8-10 each, widely available Oral-B iO heads: ~$12-15 each, less common

Over 2 years with quarterly replacements, the ProtectiveClean saves ~$30-50 on brush heads alone.

Noise Level

Winner: Oral-B iO Series 5

The iO magnetic drive system is significantly quieter than the ProtectiveClean's sonic motor. If you brush while others are sleeping, the iO's whisper-quiet operation is noticeable.

Who Should Buy Which?

Choose Philips Sonicare ProtectiveClean 5300 if:

• You want proven Sonicare technology at the best value
• You don't need smart features or app connectivity
• You prefer longer battery life
• You want lower long-term replacement costs
• You're upgrading from a manual toothbrush and want to start simple

Choose Oral-B iO Series 5 if:

• You want AI-guided brushing with real-time feedback
• You appreciate the interactive display
• You prefer oscillating technology for gumline cleaning
• You want quiet operation
• You're willing to pay more for premium features

Bottom Line

Both the ProtectiveClean 5300 and iO Series 5 are excellent mid-range choices. The ProtectiveClean 5300 is the smart buy if you want proven sonic cleaning without complexity. The iO Series 5 is worth the premium if you value smart features and prefer oscillating technology. Either will transform your oral care routine compared to manual brushing.